Occupational and Environmental Medicine

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Editor-De Cock et al` note that waiting times to conception are significantly longer in the wives of men exposed to pesticides. They cite the evidence that the nematocide dibromochloropropane (DBCP) is associated with diminished sperm counts.2 It is worth noting that there is other evidence of hazard in these men. They reportedly have significantly high gonadotrophin concentrations although their testosterone concentrations remain normal.' I have hypothesised that the sexes of human offspring are associated with the hormone concentrations of their parents at the time of conception, high testosterone producing boys, and high gonadotrophin, girls.s7 In conformity with this hypothesis, there is a highly significant excess of daughters among the offspring of male DBCP applicators." So it would be interesting to know whether there was an excess of daughters among the 91 children sired by the pesticide workers studied by de Cock et al.I More generally, workers in industrial medicine might consider offspring sex ratios as a criterion of reproductive hazard: they are cheaply and painlessly ascertained, and are

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تاریخ انتشار 2005